Plasma Rich Growth Factor (or PRGF) is a type of plasma rich protein (PRP) that is derived by fractioning blood into its components. PRGF is used primarily in bone and soft tissue regeneration. It is a technique that uses a small amount of the patients own blood to isolate crucial proteins that stimulate healing, foster new bone growth, and repair soft tissue in surgical sites. And, because PRGF is derived from the patient’s own blood and tissue, the process is very safe with little risk of disease transmission or rejection from the donor.
Dr. Rob would tell you that simply put, PRP is the "lighter fluid" to bone healing. It begins the healing process immediately and for the next 6-8 hours. PRF takes over from there and offers additonally helaing factors for the next 28 to 30 days, guiding you to a success... all made from your own body!
PRGF is considered a breakthrough in bone and soft tissue regeneration because it permits the body to take advantage of the normal healing pathways at a greatly accelerated rate. When the body is wounded and needs to heal, many different cells and cell-types are rushed to the site of the injury. These cells initiate the healing process by forming blood clots and releasing growth factors into the wound. The more growth factors that are introduced to the wound, the quicker and more efficiently the body is able to heal.
By introducing PRGF to the surgical area, the body is able to take advantage of a large amount of growth factors without the blood cells. This allows for accelerated healing but without the immune system response of swelling and inflammation. PRGF also has been shown to increase the formation of new bone. By adding PRGF to the surgical site, the doctor can now grow bone more predictably and faster than ever before. This is of great significance when placing dental implants.
What are platelet rich plasma and platelet rich fibrin, and why do you recommend their use?
This question might best be answered by another question......one that we ask our patients that are planning to have tooth extraction, wisdom tooth extraction, implants, bone grafting or gum grafting procedures with us. The question is this:
If you could do something that was scientifically proven to enhance your body’s own healing and regeneration systems, that would decrease your chances of having post operative complications and help attain better healing and better results for your dental surgery, that was safe and did not require any medicines, chemicals, or donor cells other than having a small amount of your own blood drawn, and that was relatively inexpensive -- would you want to do that?
It sounds almost too good to be true, and yet this could serve as a description and rationale of the use of platelet rich plasma and platelet rich fibrin in our practice.
Platelet rich plasma is a liquid form, and platelet rich fibrin is a gelled membrane form of the products that we make from a small quantity of blood that we take from the patient just before their dental procedure. This blood is drawn in test tubes and then spun in a centrifuge which separates the blood into it’s individual components: 1. plasma, 2. red blood cells and 3. a small but very concentrated quantity of white blood cells and platelets called the buffy coat. It’s this buffy coat layer that contains the healing and growth factors that we use to enhance healing.
These products, processed from your own blood are then immediately placed into the surgical site. The scientifically proven positive effects of this procedure include better and faster soft tissue (gums) and hard tissue (bone) healing and regeneration. Because the healing occurs faster than usual, there is less chance of infection, dry socket, failed implants or failed grafting. These procedures are especially helpful to those who otherwise might have impaired healing such as diabetics , smokers, and others with chronic or acute conditions which can interfere with healing.
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